منابع مشابه
High-Throughput SNP Genotyping
Whole genome approaches using single nucleotide polymorphism (SNP) markers have the potential to transform complex disease genetics and expedite pharmacogenetics research. This has led to a requirement for high-throughput SNP genotyping platforms. Development of a successful high-throughput genotyping platform depends on coupling reliable assay chemistry with an appropriate detection system to ...
متن کاملAn Automated Allele-calling System for High-throughput Microsatellite Genotyping
Microsatellite markers are widely used for genetic analysis in biomedical research, agriculture, population and evolutionary biology, as well as for forensics and diagnostics. Advances in laboratory automation and data collection have increased the throughput and have reduced the cost of large-scale genotyping. One step in the measurement process that still needs improvement is “allele calling”...
متن کاملAn integrated system for high throughput TaqManTM based SNP genotyping
UNLABELLED We have developed an integrated laboratory information system that allows the flexible handling of pedigree, phenotype and genotype information. Specifically, it includes client applications for an integrated data import from TaqMan typing files, Mendel checking, data export, handling of pedigree and phenotype information and analysis features. AVAILABILITY The SQL source code, sou...
متن کاملHigh-throughput genotyping with single nucleotide polymorphisms.
To make large-scale association studies a reality, automated high-throughput methods for genotyping with single-nucleotide polymorphisms (SNPs) are needed. We describe PCR conditions that permit the use of the TaqMan or 5' nuclease allelic discrimination assay for typing large numbers of individuals with any SNP and computational methods that allow genotypes to be assigned automatically. To dem...
متن کاملWTSI High-throughput Genotyping Quality Assessment & Control
Description The Genotyping Facility at the Wellcome Trust Sanger Institute (WTSI) is operated by Team 67 – Genetics of complex traits in humans, led by Panos Deloukas. While the quality control (QC) pipeline extends from sample reception (DNA collections team) to the secure end-point dissemination of the genotype data, herein we concentrate primarily on the bioinformatic characterization and fi...
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ژورنال
عنوان ژورنال: Genome Research
سال: 1996
ISSN: 1088-9051
DOI: 10.1101/gr.6.9.781